Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV

CMX157 is a lipid (1-0-hexadecyloxypropyl) conjugate of the acyclic nucleotide analog tenofovir (TFV) with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. CMX157 was consistently >300-fold more acti...

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Main Authors: Lanier, E. Randall, Ptak, Roger G., Lampert, Bernhard M., Keilholz, Laurie, Hartman, Tracy, Buckheit, Robert W., Mankowski, Marie K., Osterling, Mark C., Almond, Merrick R., Painter, George R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897300/
https://ncbi.nlm.nih.gov/pubmed/20439609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00068-10
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