Inhibition of FOXO3 Tumor Suppressor Function by βTrCP1 through Ubiquitin-Mediated Degradation in a Tumor Mouse Model

BACKGROUND: The ubiquitin-proteasome system is the primary proteolysis machine for controlling protein stability of the majority of regulatory proteins including those that are critical for cancer development. The forkhead box transcription factor FOXO3 plays a key role in regulating tumor suppressi...

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Main Authors: Tsai, Wen-Bin, Chung, Young Min, Zou, Yiyu, Park, See-Hyoung, Xu, Zhaohui, Nakayama, Keiko, Lin, Sue-Hwa, Hu, Mickey C-T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896402/
https://ncbi.nlm.nih.gov/pubmed/20625400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011171
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