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Structure of the human mTOR Complex I and its implications for rapamycin inhibition
The mammalian Target of Rapamycin Complex 1 (mTORC1) regulates cell growth in response to the nutrient and energy status of the cell, and its deregulation is common in human cancers. Little is known about the overall architecture and subunit organization of this essential signaling complex. We have...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887672/ https://ncbi.nlm.nih.gov/pubmed/20542007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.05.017 |
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