Conserved Water-mediated Hydrogen Bond Network between TM-I, -II, -VI, and -VII in 7TM Receptor Activation

Five highly conserved polar residues connected by a number of structural water molecules together with two rotamer micro-switches, TrpVI:13 and TyrVII:20, constitute an extended hydrogen bond network between the intracellular segments of TM-I, -II, -VI, and -VII of 7TM receptors. Molecular dynamics...

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Détails bibliographiques
Auteurs principaux: Nygaard, Rie, Valentin-Hansen, Louise, Mokrosinski, Jacek, Frimurer, Thomas M., Schwartz, Thue W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885241/
https://ncbi.nlm.nih.gov/pubmed/20395291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.106021
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