Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). In inhibited autoxidations we find that ApAP,...

Full description

Saved in:
Bibliographic Details
Main Authors: Nam, Tae-gyu, Nara, Susheel J., Zagol-Ikapitte, Irène, Cooper, Thomas, Valgimigli, Luca, Oates, John A., Porter, Ned A., Boutaud, Olivier, Pratt, Derek A.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873786/
https://ncbi.nlm.nih.gov/pubmed/20024105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b912528k
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items