Levuglandin Forms Adducts with Histone H4 in a Cyclooxygenase-2-Dependent Manner, Altering Its Interaction with DNA

[Image: see text] Inflammation and subsequent cyclooxygenase-2 (COX-2) activity has long been linked with the development of cancer, although little is known about any epigenetic effects of COX-2. A product of COX-2 activation, levuglandin (LG) quickly forms covalent bonds with nearby primary amines...

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Bibliographic Details
Main Authors: Carrier, Erica J., Zagol-Ikapitte, Irene, Amarnath, Venkataraman, Boutaud, Olivier, Oates, John A.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004227/
https://ncbi.nlm.nih.gov/pubmed/24684440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401673b
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