CHARACTERIZATION OF COVALENT ADDUCTS OF NUCLEOSIDES AND DNA FORMED BY REACTION WITH LEVUGLANDIN

Increased expression of cyclooxygenase-2 (COX-2) is associated with development of several cancers. The product of COX-2, prostaglandin H2 (PGH(2)), can undergo spontaneous rearrangement and nonenzymatic ring cleavage to form the highly reactive levuglandin E2 (LGE(2)) or D2 (LGD(2)). Incubation wit...

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Hlavní autoři: Carrier, Erica J., Amarnath, Venkataraman, Oates, John A., Boutaud, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824920/
https://ncbi.nlm.nih.gov/pubmed/19824699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9015132
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