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Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies

We report the development of a sensitive liquid chromatography–tandem mass spectrometric assay to quantitate 3-methoxysalicylamine (3-MoSA) in biological samples. Derivatization with 1,1’-thiocarbonyldiimidazole followed by C(18) reverse-phase chromatography allowed the detection of both analyte and...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Zagol-Ikapitte, Irene, Amarnath, Venkataraman, Jadhav, Satyawan, Oates, John A., Boutaud, Olivier
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091354/
https://ncbi.nlm.nih.gov/pubmed/21489890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2011.03.026
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