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Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies
We report the development of a sensitive liquid chromatography–tandem mass spectrometric assay to quantitate 3-methoxysalicylamine (3-MoSA) in biological samples. Derivatization with 1,1’-thiocarbonyldiimidazole followed by C(18) reverse-phase chromatography allowed the detection of both analyte and...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3091354/ https://ncbi.nlm.nih.gov/pubmed/21489890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2011.03.026 |
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