Pharmacokinetic study of ACT-132577 in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry

It was reported that macitentan was metabolized predominantly by cytochrome P450 3A4, and ACT-132577, its pharmacologically active metabolite, is fivefold less potent at blocking ET receptors than macitentan. In this work, a sensitive and selective ultra performance liquid chromatography-tandem mass...

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Detalhes bibliográficos
Publicado no:Int J Clin Exp Med
Main Authors: Zhang, Jin, Geng, Peiwu, Luo, Xinhua, Zhou, Genzhi, Lin, Yingying, Zhang, Lijing, Wang, Shuanghu, Wen, Congcong, Ma, Jianshe, Ding, Ting
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694347/
https://ncbi.nlm.nih.gov/pubmed/26770447
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