Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues

[Image: see text] Acetaminophen (ApAP) is an electron donor capable of reducing radicals generated by redox cycling of hemeproteins. It acts on the prostaglandin H synthases (cyclooxygenases; COXs) to reduce the protoporphyrin radical cation in the peroxidase site of the enzyme, thus preventing the...

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Huvudupphovsmän: Shchepin, Roman V., Liu, Wei, Yin, Huiyong, Zagol-Ikapitte, Irene, Amin, Taneem, Jeong, Byeong-Seon, Roberts, L. Jackson, Oates, John A., Porter, Ned A., Boutaud, Olivier
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2013
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904457/
https://ncbi.nlm.nih.gov/pubmed/24482730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000904
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