Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis

Herein we report an investigation of the efficacy of pyridine and pyrimidine analogs of acetaminophen (ApAP) as peroxyl radical-trapping antioxidants and inhibitors of enzyme-catalyzed lipid peroxidation by cyclooxygenases (COX) and lipoxygenases (LOX). In inhibited autoxidations we find that ApAP,...

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Detalhes bibliográficos
Main Authors: Nam, Tae-gyu, Nara, Susheel J., Zagol-Ikapitte, Irène, Cooper, Thomas, Valgimigli, Luca, Oates, John A., Porter, Ned A., Boutaud, Olivier, Pratt, Derek A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873786/
https://ncbi.nlm.nih.gov/pubmed/20024105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b912528k
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