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Protease-Activated Receptor Signaling in Platelets Activates Cytosolic Phospholipase A(2)(α) Differently for Cyclooxygenase-1 and 12-Lipoxygenase Catalysis
OBJECTIVE: The rate-limiting step in the biosynthesis of thromboxane A(2) (TxA(2)) and 12-hydroxyeicosatetraenoic acid (12-HETE) by platelets is activation of cytosolic phospholipase A(2)(α) (cPLA(2)(α)), which releases arachidonic acid, which is the substrate for cyclooxygenase-1 (COX-1) and 12-lip...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3035574/ https://ncbi.nlm.nih.gov/pubmed/21127289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.219527 |
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