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Endoplasmic Reticulum Ca(2+) Increases Enhance Mutant Glucocerebrosidase Proteostasis
Altering intracellular calcium levels is known to partially restore mutant enzyme homeostasis in several lysosomal storage diseases, but why? We hypothesize that endoplasmic reticulum (ER) calcium level increases enhance the folding, trafficking and function of these mutant misfolding/degradation-pr...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2873071/ https://ncbi.nlm.nih.gov/pubmed/20453863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.368 |
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