ERdj3 is an Endoplasmic Reticulum Degradation Factor for Mutant Glucocerebrosidase Variants Linked to Gaucher’s Disease

Gaucher’s disease (GD) is caused by mutations that compromise β-glucocerebrosidase (GCase) folding in the endoplasmic reticulum (ER), leading to excessive degradation instead of trafficking, which results in insufficient lysosomal function. We hypothesized that ER GCase interacting proteins play cri...

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Detaylı Bibliyografya
Asıl Yazarlar: Tan, Yun Lei, Genereux, Joseph C., Pankow, Sandra, Aerts, Johannes M.F.G., Yates, John R., Kelly, Jeffery W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136546/
https://ncbi.nlm.nih.gov/pubmed/25126989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.06.008
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