Proteostasis Regulators and Pharmacologic Chaperones Synergize to Correct Protein Misfolding Diseases

Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking and degradation. We demonstrate that the innate cellular protein homeostasis, or proteostasis, capacity can be enhanced to f...

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Detaylı Bibliyografya
Asıl Yazarlar: Mu, Ting-Wei, Ong, Derrick Sek Tong, Wang, Ya-Juan, Balch, William E., Yates, John R., Segatori, Laura, Kelly, Jeffery W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650088/
https://ncbi.nlm.nih.gov/pubmed/18775310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.037
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