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Proteostasis Regulators and Pharmacologic Chaperones Synergize to Correct Protein Misfolding Diseases
Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking and degradation. We demonstrate that the innate cellular protein homeostasis, or proteostasis, capacity can be enhanced to f...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650088/ https://ncbi.nlm.nih.gov/pubmed/18775310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.06.037 |
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