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Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
Phenylketonuria (PKU) is a loss-of-function inborn error of metabolism. As many other inherited diseases the main pathologic mechanism in PKU is an enhanced tendency of the mutant phenylalanine hydroxylase (PAH) to misfold and undergo ubiquitin-dependent degradation. Recent alternative approaches wi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Bentham Science Publishers
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3664513/ https://ncbi.nlm.nih.gov/pubmed/23339306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568026611212220008 |
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