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Using pharmacological chaperones to restore proteostasis
Normal organismal physiology depends on the maintenance of proteostasis in each cellular compartment to achieve a delicate balance between protein synthesis, folding, trafficking, and degradation while minimizing misfolding and aggregation. Defective proteostasis leads to numerous protein misfolding...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4070435/ https://ncbi.nlm.nih.gov/pubmed/24747662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2014.04.002 |
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