Proteostasis regulators restore function of epilepsy-associated GABA(A) receptors

Proteostasis deficiency in mutated ion channels leads to a variety of ion channel diseases that are caused by excessive endoplasmic reticulum-associated degradation (ERAD) and inefficient membrane trafficking. We investigated proteostasis maintenance of γ-aminobutyric acid type A (GABA(A)) receptors...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Di, Xiao-Jing, Wang, Ya-Juan, Cotter, Edmund, Wang, Meng, Whittsette, Angela L, Han, Dong-Yun, Sangwung, Panjamaporn, Brown, Renae, Lynch, Joseph W, Keramidas, Angelo, Mu, Ting-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855620/
https://ncbi.nlm.nih.gov/pubmed/32888501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.08.012
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