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SAHA Enhances Proteostasis of Epilepsy-Associated α1(A322D)β2γ2 GABA(a) Receptors
GABA(a) receptors are the primary inhibitory ion channels in the mammalian central nervous system. The A322D mutation in the α1 subunit of GABA(a) receptors is known to result in its degradation and reduce its cell surface expression, leading to loss of GABA(a) receptor function in autosomal dominan...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3872227/ https://ncbi.nlm.nih.gov/pubmed/24211135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.09.020 |
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