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SAHA (Vorinostat) Corrects Inhibitory Synaptic Deficits Caused by Missense Epilepsy Mutations to the GABA(A) Receptor γ2 Subunit
The GABA(A) receptor (GABA(A)R) α1 subunit A295D epilepsy mutation reduces the surface expression of α1(A295D)β2γ2 GABA(A)Rs via ER-associated protein degradation. Suberanilohydroxamic acid (SAHA, also known as Vorinostat) was recently shown to correct the misfolding of α1(A295D) subunits and thereb...
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| Publicado no: | Front Mol Neurosci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5876238/ https://ncbi.nlm.nih.gov/pubmed/29628874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00089 |
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