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Zolpidem and eszopiclone prime α1β2γ2 GABA(A) receptors for longer duration of activity

BACKGROUND AND PURPOSE: GABA(A) receptors mediate neuronal inhibition in the brain. They are the primary targets for benzodiazepines, which are widely used to treat neurological disorders including anxiety, epilepsy and insomnia. The mechanism by which benzodiazepines enhance GABA(A) receptor activi...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Dixon, Christine L, Harrison, Neil L, Lynch, Joseph W, Keramidas, Angelo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507157/
https://ncbi.nlm.nih.gov/pubmed/25817320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13142
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