Endoplasmic Reticulum Ca(2+) Increases Enhance Mutant Glucocerebrosidase Proteostasis

Altering intracellular calcium levels is known to partially restore mutant enzyme homeostasis in several lysosomal storage diseases, but why? We hypothesize that endoplasmic reticulum (ER) calcium level increases enhance the folding, trafficking and function of these mutant misfolding/degradation-pr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ong, Derrick Sek Tong, Mu, Ting-Wei, Palmer, Amy E., Kelly, Jeffery W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873071/
https://ncbi.nlm.nih.gov/pubmed/20453863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.368
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