Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. The ATX-LPA signaling axis has been implicated in angioge...

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Detalhes bibliográficos
Main Authors: Albers, Harald M. H. G., Dong, Anping, van Meeteren, Laurens A., Egan, David A., Sunkara, Manjula, van Tilburg, Erica W., Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J., Smyth, Susan S., Moolenaar, Wouter H., Ovaa, Huib
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867685/
https://ncbi.nlm.nih.gov/pubmed/20360563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001529107
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