Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. The ATX-LPA signaling axis has been implicated in angioge...

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Bibliographic Details
Main Authors: Albers, Harald M. H. G., Dong, Anping, van Meeteren, Laurens A., Egan, David A., Sunkara, Manjula, van Tilburg, Erica W., Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J., Smyth, Susan S., Moolenaar, Wouter H., Ovaa, Huib
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867685/
https://ncbi.nlm.nih.gov/pubmed/20360563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001529107
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