Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. The ATX-LPA signaling axis has been implicated in angioge...

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Dades bibliogràfiques
Autors principals: Albers, Harald M. H. G., Dong, Anping, van Meeteren, Laurens A., Egan, David A., Sunkara, Manjula, van Tilburg, Erica W., Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J., Smyth, Susan S., Moolenaar, Wouter H., Ovaa, Huib
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867685/
https://ncbi.nlm.nih.gov/pubmed/20360563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001529107
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