Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. The ATX-LPA signaling axis has been implicated in angioge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Albers, Harald M. H. G., Dong, Anping, van Meeteren, Laurens A., Egan, David A., Sunkara, Manjula, van Tilburg, Erica W., Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J., Smyth, Susan S., Moolenaar, Wouter H., Ovaa, Huib
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867685/
https://ncbi.nlm.nih.gov/pubmed/20360563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001529107
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