Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. The ATX-LPA signaling axis has been implicated in angioge...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Albers, Harald M. H. G., Dong, Anping, van Meeteren, Laurens A., Egan, David A., Sunkara, Manjula, van Tilburg, Erica W., Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J., Smyth, Susan S., Moolenaar, Wouter H., Ovaa, Huib
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2010
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867685/
https://ncbi.nlm.nih.gov/pubmed/20360563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001529107
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