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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer res...

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Autors principals: Nikolenko, Galina N., Delviks-Frankenberry, Krista A., Pathak, Vinay K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863829/
https://ncbi.nlm.nih.gov/pubmed/20219933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01545-09
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