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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer res...

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Hlavní autoři: Nikolenko, Galina N., Delviks-Frankenberry, Krista A., Pathak, Vinay K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863829/
https://ncbi.nlm.nih.gov/pubmed/20219933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01545-09
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