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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer res...

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Bibliografiske detaljer
Main Authors: Nikolenko, Galina N., Delviks-Frankenberry, Krista A., Pathak, Vinay K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863829/
https://ncbi.nlm.nih.gov/pubmed/20219933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01545-09
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