Subtype-Specific Differences in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Connection Subdomain of CRF01_AE Are Associated with Higher Levels of Resistance to 3′-Azido-3′-Deoxythymidine

We previously shown that mutations in the connection (CN) subdomain of human immunodeficiency virus type 1 (HIV-1) subtype B reverse transcriptase (RT) increase 3′-azido-3′-deoxythymidine (AZT) resistance in the context of thymidine analog mutations (TAMs) by affecting the balance between polymeriza...

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Detalhes bibliográficos
Main Authors: Delviks-Frankenberry, Krista A., Nikolenko, Galina N., Maldarelli, Frank, Hase, Saiki, Takebe, Yutaka, Pathak, Vinay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738196/
https://ncbi.nlm.nih.gov/pubmed/19553318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00859-09
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