Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance

We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in nucleoside reverse transcriptase inhibitor (NRTI) resistance. To explore the predictions of this concept, we analyzed the role of patient-derived C-terminal domains of HIV-1 reve...

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Autores principales: Nikolenko, Galina N., Delviks-Frankenberry, Krista A., Palmer, Sarah, Maldarelli, Frank, Fivash, Matthew J., Coffin, John M., Pathak, Vinay K.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765458/
https://ncbi.nlm.nih.gov/pubmed/17179211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609642104
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