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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn m...

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Main Authors: Delviks-Frankenberry, Krista A., Nikolenko, Galina N., Boyer, Paul L., Hughes, Stephen H., Coffin, John M., Jere, Abhay, Pathak, Vinay K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491488/
https://ncbi.nlm.nih.gov/pubmed/18667707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804660105
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