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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision
We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn m...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2491488/ https://ncbi.nlm.nih.gov/pubmed/18667707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804660105 |
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