HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

We previously proposed that mutations in the connection subdomain (cn) of HIV-1 reverse transcriptase increase AZT resistance by altering the balance between nucleotide excision and template RNA degradation. To test the predictions of this model, we analyzed the effects of previously identified cn m...

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Autores principales: Delviks-Frankenberry, Krista A., Nikolenko, Galina N., Boyer, Paul L., Hughes, Stephen H., Coffin, John M., Jere, Abhay, Pathak, Vinay K.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491488/
https://ncbi.nlm.nih.gov/pubmed/18667707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804660105
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