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A Novel Molecular Mechanism of Dual Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer res...

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書誌詳細
主要な著者: Nikolenko, Galina N., Delviks-Frankenberry, Krista A., Pathak, Vinay K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863829/
https://ncbi.nlm.nih.gov/pubmed/20219933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01545-09
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