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Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell–ce...

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Bibliografski detalji
Glavni autori: Stockton, Rebecca A., Shenkar, Robert, Awad, Issam A., Ginsberg, Mark H.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856024/
https://ncbi.nlm.nih.gov/pubmed/20308363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091258
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