Vascular permeability in cerebral cavernous malformations

Patients with the familial form of cerebral cavernous malformations (CCMs) are haploinsufficient for the CCM1, CCM2, or CCM3 gene. Loss of corresponding CCM proteins increases RhoA kinase-mediated endothelial permeability in vitro, and in mouse brains in vivo. A prospective case-controlled observati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cereb Blood Flow Metab
Prif Awduron: Mikati, Abdul G, Khanna, Omaditya, Zhang, Lingjiao, Girard, Romuald, Shenkar, Robert, Guo, Xiaodong, Shah, Akash, Larsson, Henrik BW, Tan, Huan, Li, Luying, Wishnoff, Matthew S, Shi, Changbin, Christoforidis, Gregory A, Awad, Issam A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640319/
https://ncbi.nlm.nih.gov/pubmed/25966944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2015.98
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