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Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
Endothelial cell–cell junctions regulate vascular permeability, vasculogenesis, and angiogenesis. Familial cerebral cavernous malformations (CCMs) in humans result from mutations of CCM2 (malcavernin, OSM, MGC4607), PDCD10 (CCM3), or KRIT1 (CCM1), a Rap1 effector which stabilizes endothelial cell–ce...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856024/ https://ncbi.nlm.nih.gov/pubmed/20308363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091258 |
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