RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

BACKGROUND AND PURPOSE: We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor, and simvastatin (with pleiotropic effects including ROCK inhibition) on cerebral cavernous malformation (CCM) genesis and maturation in two...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stroke
Prif Awduron: Shenkar, Robert, Shi, Changbin, Austin, Cecilia, Moore, Thomas, Lightle, Rhonda, Cao, Ying, Zhang, Lingjiao, Wu, Meijing, Zeineddine, Hussein A., Girard, Romuald, McDonald, David A., Rorrer, Autumn, Gallione, Carol, Pytel, Peter, Liao, James K., Marchuk, Douglas A., Awad, Issam A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183488/
https://ncbi.nlm.nih.gov/pubmed/27879448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.116.015013
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