Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are expressed constitutively. Nevertheless, a synthetic inhibitor (SU5416) of VEGF signalling impairs an...

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Hlavní autoři: Bergers, Gabriele, Brekken, Rolf, McMahon, Gerald, Vu, Thiennu H., Itoh, Takeshi, Tamaki, Kazuhiko, Tanzawa, Kazuhiko, Thorpe, Philip, Itohara, Shigeyoshi, Werb, Zena, Hanahan, Douglas
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852586/
https://ncbi.nlm.nih.gov/pubmed/11025665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35036374
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