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MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Homozygous mice with a null mutation in the MMP-9/ gelatinase B gene exhibit an abnormal pattern of skeletal growth plate vascularization and ossification. Although hypertrophic chondrocytes develop normally, apoptosis, vascularization, and ossification are delayed, resulting in progressive lengthen...

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Autors principals: Vu, Thiennu H., Shipley, J. Michael, Bergers, Gabriele, Berger, Joel E., Helms, Jill A., Hanahan, Douglas, Shapiro, Steven D., Senior, Robert M., Werb, Zena
Format: Artigo
Idioma:Inglês
Publicat: 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839071/
https://ncbi.nlm.nih.gov/pubmed/9590175
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