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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a multistage pathway to squamous carcinoma. We report that infiltration by mast cells and activation of the matrix metalloproteinase MMP-9/gelatinase B coincides with the angiogenic switch in premalignant lesion...

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Detalhes bibliográficos
Main Authors: Coussens, Lisa M., Raymond, Wilfred W., Bergers, Gabriele, Laig-Webster, Marion, Behrendtsen, Ole, Werb, Zena, Caughey, George H., Hanahan, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316772/
https://ncbi.nlm.nih.gov/pubmed/10364156
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