Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are expressed constitutively. Nevertheless, a synthetic inhibitor (SU5416) of VEGF signalling impairs an...

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Detalhes bibliográficos
Main Authors: Bergers, Gabriele, Brekken, Rolf, McMahon, Gerald, Vu, Thiennu H., Itoh, Takeshi, Tamaki, Kazuhiko, Tanzawa, Kazuhiko, Thorpe, Philip, Itohara, Shigeyoshi, Werb, Zena, Hanahan, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852586/
https://ncbi.nlm.nih.gov/pubmed/11025665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/35036374
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