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Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation

Long bone development depends on endochondral bone formation, a complex process requiring exquisite balance between hypertrophic cartilage (HC) formation and its ossification. Dysregulation of this process may result in skeletal dysplasias and heterotopic ossification. Endochondral ossification requ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ortega, Nathalie, Wang, Ke, Ferrara, Napoleone, Werb, Zena, Vu, Thiennu H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Limited 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869494/
https://ncbi.nlm.nih.gov/pubmed/20142327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.004226
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