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Structural basis underlying the dual gate properties of KcsA

KcsA is a prokaryotic pH-dependent potassium (K) channel. Its activation, by a decrease in the intracellular pH, is coupled with its subsequent inactivation, but the underlying mechanisms remain elusive. Here, we have investigated the conformational changes and equilibrium of KcsA by using solution...

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Detalhes bibliográficos
Main Authors: Imai, Shunsuke, Osawa, Masanori, Takeuchi, Koh, Shimada, Ichio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852003/
https://ncbi.nlm.nih.gov/pubmed/20212150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911270107
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