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Structural basis underlying the dual gate properties of KcsA

KcsA is a prokaryotic pH-dependent potassium (K) channel. Its activation, by a decrease in the intracellular pH, is coupled with its subsequent inactivation, but the underlying mechanisms remain elusive. Here, we have investigated the conformational changes and equilibrium of KcsA by using solution...

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Bibliografske podrobnosti
Main Authors: Imai, Shunsuke, Osawa, Masanori, Takeuchi, Koh, Shimada, Ichio
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852003/
https://ncbi.nlm.nih.gov/pubmed/20212150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911270107
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