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Structural basis underlying the dual gate properties of KcsA

KcsA is a prokaryotic pH-dependent potassium (K) channel. Its activation, by a decrease in the intracellular pH, is coupled with its subsequent inactivation, but the underlying mechanisms remain elusive. Here, we have investigated the conformational changes and equilibrium of KcsA by using solution...

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Hlavní autoři: Imai, Shunsuke, Osawa, Masanori, Takeuchi, Koh, Shimada, Ichio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852003/
https://ncbi.nlm.nih.gov/pubmed/20212150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911270107
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