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Functional Equilibrium of the KcsA Structure Revealed by NMR

KcsA is a tetrameric K(+) channel that is activated by acidic pH. Under open conditions of the helix bundle crossing, the selectivity filter undergoes an equilibrium between permeable and impermeable conformations. Here we report that the population of the permeable conformation (p(perm)) positively...

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Detalhes bibliográficos
Main Authors: Imai, Shunsuke, Osawa, Masanori, Mita, Kenichiro, Toyonaga, Shou, Machiyama, Asako, Ueda, Takumi, Takeuchi, Koh, Oiki, Shigetoshi, Shimada, Ichio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501015/
https://ncbi.nlm.nih.gov/pubmed/23024361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401265
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