Functional Equilibrium of the KcsA Structure Revealed by NMR

KcsA is a tetrameric K(+) channel that is activated by acidic pH. Under open conditions of the helix bundle crossing, the selectivity filter undergoes an equilibrium between permeable and impermeable conformations. Here we report that the population of the permeable conformation (p(perm)) positively...

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Bibliografski detalji
Glavni autori: Imai, Shunsuke, Osawa, Masanori, Mita, Kenichiro, Toyonaga, Shou, Machiyama, Asako, Ueda, Takumi, Takeuchi, Koh, Oiki, Shigetoshi, Shimada, Ichio
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501015/
https://ncbi.nlm.nih.gov/pubmed/23024361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401265
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