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Conformational equilibrium shift underlies altered K(+) channel gating as revealed by NMR

The potassium ion (K(+)) channel plays a fundamental role in controlling K(+) permeation across the cell membrane and regulating cellular excitabilities. Mutations in the transmembrane pore reportedly affect the gating transitions of K(+) channels, and are associated with the onset of neural disorde...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Iwahashi, Yuta, Toyama, Yuki, Imai, Shunsuke, Itoh, Hiroaki, Osawa, Masanori, Inoue, Masayuki, Shimada, Ichio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560842/
https://ncbi.nlm.nih.gov/pubmed/33057011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19005-3
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