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Conformational equilibrium shift underlies altered K(+) channel gating as revealed by NMR
The potassium ion (K(+)) channel plays a fundamental role in controlling K(+) permeation across the cell membrane and regulating cellular excitabilities. Mutations in the transmembrane pore reportedly affect the gating transitions of K(+) channels, and are associated with the onset of neural disorde...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7560842/ https://ncbi.nlm.nih.gov/pubmed/33057011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19005-3 |
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