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Functional Equilibrium of the KcsA Structure Revealed by NMR
KcsA is a tetrameric K(+) channel that is activated by acidic pH. Under open conditions of the helix bundle crossing, the selectivity filter undergoes an equilibrium between permeable and impermeable conformations. Here we report that the population of the permeable conformation (p(perm)) positively...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501015/ https://ncbi.nlm.nih.gov/pubmed/23024361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401265 |
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