Functional Equilibrium of the KcsA Structure Revealed by NMR

KcsA is a tetrameric K(+) channel that is activated by acidic pH. Under open conditions of the helix bundle crossing, the selectivity filter undergoes an equilibrium between permeable and impermeable conformations. Here we report that the population of the permeable conformation (p(perm)) positively...

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Hlavní autoři: Imai, Shunsuke, Osawa, Masanori, Mita, Kenichiro, Toyonaga, Shou, Machiyama, Asako, Ueda, Takumi, Takeuchi, Koh, Oiki, Shigetoshi, Shimada, Ichio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501015/
https://ncbi.nlm.nih.gov/pubmed/23024361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401265
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