Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element

HIV-1 Rev is a small regulatory protein that mediates the nuclear export of viral mRNAs, an essential step in the HIV replication cycle. In this process Rev oligomerizes in association with a highly structured RNA motif, the Rev response element. Crystallographic studies of Rev have been hampered by...

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Bibliographische Detailangaben
Hauptverfasser: DiMattia, Michael A., Watts, Norman R., Stahl, Stephen J., Rader, Christoph, Wingfield, Paul T., Stuart, David I., Steven, Alasdair C., Grimes, Jonathan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851902/
https://ncbi.nlm.nih.gov/pubmed/20231488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914946107
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