Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev

Rev is a key regulatory protein of HIV-1. Its function is to bind to viral transcripts and effect export from the nucleus of unspliced mRNA thereby allowing the synthesis of structural proteins. Despite its evident importance, the structure of Rev has remained unknown, primarily because Rev’s procli...

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Main Authors: Stahl, Stephen J., Watts, Norman R., Rader, Christoph, Dimattia, Michael A., Mage, Rose G., Palmer, Ira, Kaufman, Joshua D., Grimes, Jonathan M., Stuart, David I., Steven, Alasdair C., Wingfield, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851401/
https://ncbi.nlm.nih.gov/pubmed/20138059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.061
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